解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Muscle blood flow (MBF) and muscle oxygen saturation (SmO(2)) were measured at eight locations (four proximal, four distal) over a 4 x 8 cm(2) area of the vastus lateralis at rest and immediately after isometric, maximal quadriceps contraction using multichannel, frequency-domain, near-infrared spectroscopy. A venous ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1646417
更新日期:2004-03-01 00:00:00
abstract::Optical coherence tomography (OCT) is an emerging technology for high-resolution, noncontact imaging of transparent and scattering media. Polarization-sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT that can image birefringent properties of a biological sample. PS-OCT was used to measu...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1629308
更新日期:2004-01-01 00:00:00
abstract::In all fundus laser treatments of the eye, the temperature increase is not exactly known. In order to optimize treatments, an online temperature determination is preferable. We investigated a noninvasive optoacoustic method to monitor the fundus temperature during pulsed laser irradiation. When laser pulses are applie...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1627338
更新日期:2004-01-01 00:00:00
abstract::The spatiotemporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of alpha-chloralose-urethane anesthetized rats (n=10) with optical imaging at 570 nm through a thinned skull. Activation of the cortex was carried out by elect...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1609199
更新日期:2003-10-01 00:00:00
abstract::Fluorescence lifetime imaging microscopy (FLIM) using multiphoton excitation techniques is now finding an important place in quantitative imaging of protein-protein interactions and intracellular physiology. Recent developments in multiphoton FLIM methods are reviewed and a novel multiphoton FLIM system using a streak...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1577574
更新日期:2003-07-01 00:00:00
abstract::Image resolution and signal level in fluorescence microscopy through inhomogeneous turbid media consisting of scatterers of multiple sizes under single- (1p), two- (2p), and three-photon (3p) excitation have been investigated based on a modified Monte Carlo model. The effects of the size distribution and the concentra...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1577116
更新日期:2003-07-01 00:00:00
abstract::Pulse oximeters are widely used for noninvasive monitoring of oxygen saturation in arterial blood hemoglobin. We present a transmittance pulse oximetry system based on near-infrared (NIR) laser diodes (750 and 850 nm) for monitoring oxygen saturation of arterial blood hemoglobin. The pulse oximetry system is made up o...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1578495
更新日期:2003-07-01 00:00:00
abstract::We compared light-induced fluorescence (LIF) to nominal injected drug dose for predicting the depth of necrosis response to photodynamic therapy (PDT) in a murine tumor model. Mice were implanted with radiation-induced fibrosarcoma (RIF) and were injected with 0, 5, or 10 mg/kg Photofrin. 630-nm light (30 J/cm(2), 75 ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1560011
更新日期:2003-04-01 00:00:00
abstract::This study investigates the correlation of tumor blood oxygenation and tumor pO(2) with respect to carbogen inhalation. After having refined and validated the algorithms for calculating hemoglobin concentrations, we used near-infrared spectroscopy (NIRS) to measure changes of oxygenated hemoglobin concentration (delta...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1527049
更新日期:2003-01-01 00:00:00
abstract::Our aim is the development of a simple optical method for pulse wave profile, pulse wave delay time, and blood flow measurement. The method is based on recording the Doppler frequency shift related to a moving target--blood vessel walls or small particles. The Doppler signal is detected using the self-mixing that occu...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1528949
更新日期:2003-01-01 00:00:00
abstract::We investigate optoelectronic properties of integrated structures comprising semiconductor light-emitting materials for optical probes of microscopic biological systems. Compound semiconductors are nearly ideal light emitters for probing cells and other microorganisms because of their spectral match to the transparenc...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1506931
更新日期:2002-10-01 00:00:00
abstract::New diagnostic tools are needed for the characterization of dental caries in the early stages of development. If carious lesions are detected early enough, they can be arrested without the need for surgical intervention. The objective of this study was to demonstrate that polarization sensitive optical coherence tomog...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1509752
更新日期:2002-10-01 00:00:00
abstract::The scattering of polarized light from a two layer scattering medium is investigated using Monte Carlo simulations. First order and normalized second order moments are used to analyze the spatial properties of the emerging light in different polarization states. Linearly and circularly polarized illumination is used t...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1483316
更新日期:2002-07-01 00:00:00
abstract::Intracellular oxygen concentration is of primary importance in determining numerous physiological and pathological processes in biological systems. In this paper, we describe the application of the oxygen sensing indicator, ruthenium dibipyridine 4-(1"-pyrenyl)-2,2'-bipyridine chloride [Ru(bpy-pyr)(bpy)(2)], for molec...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1483082
更新日期:2002-07-01 00:00:00
abstract::A method for the prediction of the average photon pathlength in turbid media has been developed. The method is based on spatially resolved diffuse reflectance with discrete source detector distances up to 2 mm. Light reflectance was simulated using a Monte Carlo technique with a one-layer model utilizing a wide range ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1482378
更新日期:2002-07-01 00:00:00
abstract::Since hyperglycaemia changes the erythrocyte cell membrane fluidity and impairs cell deformity, our goal was to characterize hemoglobin and red blood cell (RBC) light refractive property changes in diabetic patients. Microscopic investigation was carried out on intact and fixed RBCs. To determine the refractive index ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1463043
更新日期:2002-04-01 00:00:00
abstract::Hemorrhagic hypovolemia and inotropic agent administration were used to manipulate cardiac output (CO) and oxygen delivery in rabbits to investigate the correlation between noninvasive frequency domain photon migration (FDPM) spectroscopy and invasive hemodynamic monitoring parameters. Frequency-domain photon migratio...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1427046
更新日期:2002-01-01 00:00:00
abstract::Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a n...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1428291
更新日期:2002-01-01 00:00:00
abstract::Parametric and nonparametric data processing schemes for analyzing translating laser speckle data used to investigate the mechanical behavior of biological tissues are examined. Cross-correlation, minimum mean square estimator, maximum likelihood, and maximum entropy approaches are discussed and compared on speckle da...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1412224
更新日期:2001-10-01 00:00:00
abstract::We have combined a confocal laser scanning head modified for TPE (two-photon excitation) microscopy with some spectroscopic modules to study single molecules and molecular aggregates. The behavior of the TPE microscope unit has been characterized by means of point spread function measurements and of the demonstration ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.1382809
更新日期:2001-07-01 00:00:00
abstract::A synchrotron light source dedicated to medical applications has been designed at National Institute of Radiological Sciences. The storage ring, with circumference of 80 m, is designed for acceleration of 2.3 GeV and a stored current of 420 mA. It is equipped with two multipole wigglers to produce sufficient photon fl...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1383062
更新日期:2001-07-01 00:00:00
abstract::Oxygen plays a very important role in living cells. The intracellular level of oxygen is under tight control, as even a small deviation from normal oxygen level affects major cellular metabolic processes and is likely to result in cellular damage or cell death. This paper describes the use of the oxygen sensitive fluo...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1344190
更新日期:2001-04-01 00:00:00
abstract::Higher-order optical errors of the human eye are often responsible for reduced visual acuity in spite of an optimal spherical or cylindrical refraction. These optical aberrations are of natural origin or can result from operations in the eye that involve optical structures. The ocular aberrometer presented is based on...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1344589
更新日期:2001-04-01 00:00:00
abstract::Emission and excitation spectra of collagen were recorded in the ultraviolet and visible regions. The existence of several types of chromophores absorbing and emitting throughout these spectral regions was observed. It was shown that laser irradiation at 355 and 532 nm caused collagen fluorescence photobleaching by 30...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1331559
更新日期:2001-01-01 00:00:00
abstract::This paper presents an effective two-step scheme for automatic object detection in computed radiography (CR) images. First, various structure elements of the morphological filters, designed by incorporating available morphological features of the objects of interest including their sizes and rough shape descriptions, ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1289771
更新日期:2000-10-01 00:00:00
abstract::The infrared and Raman spectroscopy of bone and teeth tissues are reviewed. Characteristic spectra are obtained for both the mineral and protein components of these tissues. Vibrational spectroscopy is used to study the mineralization process, to define the chemical structure changes accompanying bone diseases, and to...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.429994
更新日期:2000-07-01 00:00:00
abstract::The properties of polarized light emerging from turbid media in the exact backscattering direction are studied by modulating the incident light polarization state and isolating the synchronous signal with lock-in amplifier detection. The results are reported for polystyrene microsphere suspensions in distilled water, ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.430004
更新日期:2000-07-01 00:00:00
abstract::In this work experimental tissue phantoms and numerical models were developed to estimate photon migration through the fetal head in utero. The tissue phantoms incorporate a fetal head within an amniotic fluid sac surrounded by a maternal tissue layer. A continuous wave, dual-wavelength (lambda = 760 and 850 nm) spect...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429983
更新日期:2000-04-01 00:00:00
abstract::Recent technological advancements in the photonics industry have led to a resurgence of interest in optical glucose sensing and to realistic progress toward the development of an optical glucose sensor. Such a sensor has the potential to significantly improve the quality of life for the estimated 16 million diabetics ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.429962
更新日期:2000-01-01 00:00:00
abstract::In the present applications of optical coherence tomography (OCT), parameters besides pure morphology are evaluated in skin tissue under in vivo conditions. Spatially mapped refractive indices and scattering coefficients may support tissue characterization for research and diagnostic purposes in cosmetics/pharmacy and...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.429972
更新日期:2000-01-01 00:00:00
abstract::Extension of optical monitoring of intact tissues from the visible and ultraviolet to the near-infrared (NIR) range (700-1300 nm) was first undertaken in 1977 for the purpose of monitoring the redox behavior of Cytochrome c oxidase (cyt c ox) in vivo. Soon it became evident that the much greater NIR translucency of sk...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429952
更新日期:1999-10-01 00:00:00
abstract::Photospallation is proposed as the primary mechanism behind our recent animal studies involving corneal ablation by nanosecond-pulse mid-IR laser beams. Following a brief summary of earlier work directed to refractive procedures in the mid-IR, a preliminary analysis is presented, based on simple one-dimensional models...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429958
更新日期:1999-10-01 00:00:00
abstract::Virus inactivation in red blood cell concentrates (RBCC) is being studied in order to increase the safety of the blood supply. For this purpose we have been studying the silicon phthalocyanine (Pc 4), a photosensitizer activated with red light. Two approaches were used to achieve enhanced selectivity of Pc 4 for virus...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429931
更新日期:1999-07-01 00:00:00
abstract::This paper explains the term low-coherence interferometry, reviews the early development of optical low-coherence reflectometry, and shows some of the paths that led to the field of biomedical optics. This paper demonstrates that early technical developments in the telecommunications industry resulted in a myriad of t...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429914
更新日期:1999-04-01 00:00:00
abstract::Lucigenin- and luminol-dependent chemiluminescence [(LC-CL) and (LM-CL)] in nondiluted human blood was studied. LM-CL was low in fresh blood and disappeared after its storage for 3 h, though the respiratory burst (RB) stimulation in blood was followed by high intensity and long-lasting LM-CL. LC-CL was high in fresh b...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429921
更新日期:1999-01-01 00:00:00
abstract::This study investigates the precision and intraindividual variability of a clinical optical pachometer based on low-coherence reflectometry, which was used to measure the central thickness of a human cornea in vivo. The instrument, attached to a slit lamp, is a single mode fiber optic based Michelson interferometer wi...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429901
更新日期:1999-01-01 00:00:00
abstract::Laser-assisted cartilage reshaping is mediated by thermally induced stress relaxation, and may be used to alter cartilage morphology for reconstructive surgical procedures in the upper airway and face without carving, morselizing, or suturing. Internal stress σ(t), integrated backscattered light intensity I(t) from a ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429896
更新日期:1998-10-01 00:00:00
abstract::Water content is an important factor for skin condition. The determination of the hydration state of the skin is necessary to obtain basic knowledge about the penetration and loss of water in the skin stratum corneum. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is used to measure hy...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429890
更新日期:1998-07-01 00:00:00
abstract::Autofluorescence of the cornea within specific wavelength region and dynamic light scattering measurements of ocular tissue have both been used for early-stage detection of the presence of diabetic retinopathy. In the present study, autofluorescence of the cornea and dynamic light scattering in the cornea and vitreous...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429882
更新日期:1998-07-01 00:00:00
abstract::By applying linear perturbation theory to the radiation transport equation, the inverse problem of optical diffusion tomography can be reduced to a set of linear equations, Wμ=R, where W is the weight function, μ are the cross-section perturbations to be imaged, and R is the detector readings perturbations. We have st...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.429870
更新日期:1998-04-01 00:00:00